|Statement||[edited by] Peter W.T. Pisters, Murray F. Brennan.|
|Series||Medical intelligence unit|
|Contributions||Pisters, Peter W.T., Brennan, Murray F.|
|The Physical Object|
|Pagination||xv,275p. 26figs.35tabs. ;|
|Number of Pages||275|
Cancer cachexia is a complex syndrome characterized by diminished nutrient intake and progressive tissue depletion manifest clinically as anorexia and weight loss. This review examines the basic research that has addressed the fundamental derangements in host intermediary protein metabolism and. Protein and Amino Acid Metabolism in Cancer Cachexia - Ebook written by Peter W.T. Pisters, Murray F. Brennan. Read this book using Google Play Books app on your PC, android, iOS devices. Download for offline reading, highlight, bookmark or take notes while you read Protein and Amino Acid Metabolism in Cancer Cachexia. Protein and amino acid metabolism in cancer cachexia. New York: Chapman & Hall ; Austin: R.G. Landes Co., © (OCoLC) Document Type: Book: All Authors / Contributors: Peter W T Pisters; Murray F Brennan. (). Protein and Amino Acid Metabolism in Cancer Cachexia: Investigative Techniques and Therapeutic Interventions. Critical Reviews in Clinical Laboratory Sciences: Vol. 30, No. 3, .
The use of stable and unstable amino acid isotopes in these techniques is reviewed in detail. Virtually all of these techniques have now been employed in the evaluation of human cancer cachexia. The results of studies evaluating amino acid concentrations, regional amino acid balance, and 3-methylhistidine excretion are summarized. Abstract. Cancer cachexia is a complex syndrome which is associated with se vere weakness, debilitation and generalized host wasting. 1,2 Clinically this manifests as progressive tissue depletion, including skeletal muscle and visceral organ atrophy. To better understand the underlying metabolic defects which lead to these clinical findings, investigators have used a variety of research. Alterations in amino acid protein metabolism are a key feature of the cancer cachexia syndrome. Anabolic resistance—induced by both hormonal changes (that affect insulin sensitivity) and inflammatory mediators—is present in skeletal muscle and this conditions both amino acid uptake and protein synthesis. Cancer cachexia is associated with protein malnutrition and amino acid kinetics disturbances. Having said, apart from the other medical treatments that experts could offer to patients, amino acid supplementation or a high protein intake for patients are also advisable.
This review focuses on the possible relationship between inflammatory signaling and altered amino acid metabolism in cancer. RECENT FINDINGS: Loss of skeletal muscle in cancer patients can potentially be due to anorexia and early satiety, reduced muscle . heart failure . Protein or amino acid uptake, on the other hand, is either unaltered or slightly enhanced [10,12]. Malabsorption in cachexia due to chronic heart failure is thought to result from mesenteric ischemia and disturbed microcirculation of the intestine , while in cancer-associated cachexia, chemotherapies are likely. This review focuses on the possible relationship between inflammatory signaling and altered amino acid metabolism in cancer. Recent findings: Loss of skeletal muscle in cancer patients can potentially be due to anorexia and early satiety, reduced muscle protein . NSCLC patients with moderate cachexia showed considerable insulin resistance of glucose and of whole-body protein anabolism. Their anabolic protein response was stimulated normally by hyperaminoacidemia. Thus, ample provision of amino acids is a feasible strategy to overcome the protein anabolic failure of cancer cachexia.